Developing an effective quality evaluation strategy of next-generation sequencing for accurate detecting non-small cell lung cancer samples with variable characteristics: a real-world clinical practice - Journal of Cancer Research and Clinical Oncology
Source : https://link.springer.com/article/10.1007/s00432-022-04388-1
Purpose Next-generation sequencing (NGS) has been widely used in determining molecular profiling of non-small cell lung cancer (NSCLC). However, low-quality sequencing data may be generated with formalin-fixed and paraffin-embedded (FFPE)...
Conclusions: Our study demonstrates that the real-world clinical adoption of an effective QC strategy for NGS is necessary to ensure accurate results from FFPE samples of NSCLC with variable characteristics. Validation of actionable alterations by additional methods is highly recommended in cases with low QC score, particularly for the detection...
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Albert Dekker3yrbiggest question who to put all those mutations together
Knockdown of growth differentiation factor-15 inhibited nonsmall cell lung cancer through inactivating PTEN/PI3K/AKT signaling pathway - Genes & Genomics
Source : https://link.springer.com/article/10.1007/s13258-022-01328-8
Background Non-small cell lung cancer (NSCLC) is characterized by high morbidity and mortality in the world. Growth and differentiation factor 15 (GDF15) has been proved to play an important role...
Conclusions: GDF15 plays an important role in NSCLC progression. GDF15 mediated PTEN/PI3K/AKT signaling pathway might be the potential therapeutic targets for the prevention and treatment of GDF15.
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Immunochemotherapy includes pembrolizumab for stage IIIB lung squamous cell carcinoma: a case report
Source : https://atm.amegroups.com/article/view/102133/html
Lung cancer is a malignant tumor with high morbidity and mortality ( 1, 2). Conventional treatment methods include surgical treatment, chemotherapy, radiotherapy, and targeted therapy ( 3- 5). With the...
Conclusions: This case reminds us that the induction treatment pattern of pembrolizumab combined with chemotherapy for subsequent conversion surgery can be a potentially curative treatment option for locally advanced stage IIIB patients. The monitoring of thyroid-related indicators is important during immunotherapy, especially in the first...
TECPR1 Induces Apoptosis in Non-Small Cell Lung Carcinoma via ATG5 Upregulation-Induced Autophagy Promotion - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36197771/
1 Department of Pulmonary and Critical Care Medicine, Cancer Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. 2 Department of Pulmonary and Critical Care...
Conclusion: TECPR1 induces NSCLC cell apoptosis via ATG5 upregulation-induced autophagy promotion.
Predictive value of baseline metabolic tumor volume for non-small-cell lung cancer patients treated with immune checkpoint inhibitors: A meta-analysis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487526/
Ke Zhu, 1 , 2 Danqian Su, 1 , 2 Jianing Wang, 1 , 2 Zhouen Cheng, 1 , 2 Yiqiao Chin, 1 , 2 Luyin Chen, 1 , 2...
Conclusions: High level of baseline MTV corresponded to shorter PFS and OS, especially when the cut-off value was set between 50-100 cm3. MTV is a potential predictive value for the outcome of ICIs in NSCLC patients.
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Albert Dekker3yrmakes sense to some degree. It was well known with traditional chemotherapy.