Comparison of 22C3-PD-L1 Expression Between Paired Tumor... : Applied Immunohistochemistry & Molecular Morphology
ion. A total of 460 paired paraffin blocks of surgical NSCLC specimens were analyzed using the 22C3-PD-L1 assay. PD-L1 expression between 2 paired paraffin blocks was calculated using 3 classification...
Conclusions: In cases that harbored different morphology in different paraffin blocks, the dual-block immunohistochemistry assessment method is recommended due to the intratumoral heterogeneity.
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Albert Dekker3yrWe know that tumors are heterogeneous but in real life how many blocks will you test
BIR Publications
Source : https://www.birpublications.org/doi/10.1259/bjr.20210270
Therapy and prognosis of several solid and hematologic malignancies, including non-small cell lung cancer (NSCLC), have been favourably impacted by the introduction of immune checkpoint inhibitors (ICIs). Their mechanism of...
Conclusions: We will explore the role of radiomics in the setting of ICI-treated patients.
Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36331328/
Tumor immune microenvironmental marker expression, especially CD8/PD-L1 or CD68/PD-L1 co-expression, was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC.
Summary: Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy
The impact of patient travel time on disparities in treatment for early stage lung cancer in California
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272076
Background Travel time to treatment facilities may impede the receipt of guideline-concordant treatment (GCT) among patients diagnosed with early-stage non-small cell lung cancer (ES-NSCLC). We investigated the relative contribution of...
Conclusion: The benefit of GCT observed with increased travel times may be a ‘Travel Time Paradox,’ and may vary across racial/ethnic and socioeconomic groups.
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Albert Dekker3yrobviously the further people live the harder is to get
Genomic landscape of lung cancer in the young
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.910117/full
BackgroundLung cancer in the young is a rare entity of great interest due to the high frequency of targetable mutations. In this study, we explored the genomic landscape of non-small...
Conclusion: NSCLC in the young in our cohort was characterized by a high frequency of actionable genetic aberrations and a low TMB, which was also true for our older patients. The enrichment of actionable mutations in young patients described in other reports might be attributed to differences in the etiology and clinicopathological...
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Albert Dekker3yrit makes sense; younger patients have driver mutations