RELAY Subgroup Analyses by EGFR Ex19del and Ex21L858R Mutations for Ramucirumab Plus Erlotinib in Metastatic Non-small Cell Lung Cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34301751/

doi: 10.1158/1078-0432.CCR-21-0273. Online ahead of print. 1 Department of Medical Oncology, Kindai University [email protected]. 2 Department of Medical Oncology, Catalan Institute of Oncology. 3 Medicine, Hematology/Oncology, David Geffen School of...

Retrospective analysis of eleven gene mutations, PD-L1 expression and clinicopathological characteristics in non-small cell lung cancer patients - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34325991/

Mutations of EGFR, KRAS and TP53 should be routinely detected in clinical practice to better guide the immunotherapy for NSCLC patients. Future investigations are warranted to illustrate the potential mechanisms...

The safety and efficacy of erlotinib and ramucirumab combination in EGFR-mutant non-small-cell lung cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34281470/

RELAY confirmed the clinical relevance of combining EGFR and VEGF(R)-targeting therapies, previously investigated in smaller phase 2-3 trials of erlotinib and bevacizumab. However, the meaningful PFS benefit observed in the...

Phase 1b study of ramucirumab in combination with erlotinib or osimertinib for untreated EGFR-mutated non-small cell lung cancer patients with asymptomatic brain metastases - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34215931/

doi: 10.1007/s10637-021-01147-w. Online ahead of print. 1 Department of Clinical Oncology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan. [email protected]. 2 Department of Respiratory Medicine,...

[Retracted] MicroRNA‑718 serves a tumor‑suppressive role in non‑small cell lung cancer by directly targeting CCNB1 - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34296291/

Following the publication of this paper, the authors have contacted the Editorial Office to explain that they are unable to reproduce the results of their experiments designed to show the...