Identification of predictors for brain metastasis in newly diagnosed non-small cell lung cancer: a single-center cohort study - European Radiology
Source : https://link.springer.com/article/10.1007/s00330-021-08215-y
Objectives To identify clinical and staging chest CT characteristics predictive of brain metastasis in patients with newly diagnosed NSCLC dichotomized according to resectability. Methods Patients newly diagnosed with NSCLC of...
The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34353680/
Lung cancer is a highly heterogeneous disease often driven by well-characterized driver mutations. Although the best studied are common alterations in the epidermal growth factor receptor (EGFR) and anaplastic lymphoma...
Survival of Patients with Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer Treated beyond the Second Line in the Tyrosine Kinase Inhibitor Era - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34359788/
1 Oncology Department, CHU Amiens, Université de Picardie Jules Vernes, 80000 Amiens, France. 2 Oncology Department, Professeur Zafisaona Gabriel Hospital, Université de Mahajanga, Mahajanga 401, Madagascar. 3 Faculté de Médecine,...
Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34364055/
Two different schemes of novel substituted quinoline derivatives were designed and synthesized via simple reaction steps and conditions. A comparative molecular docking study was carried out on two different types...
PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34359849/
Tyrosine kinase inhibitors (TKIs) targeting the kinase domain of the epidermal growth factor receptor (EGFR), such as erlotinib, have dramatically improved clinical outcomes of patients with EGFR-driven non-small cell lung...