Precision therapy for RET-altered cancers with RET inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34391699/
Rearranged during transfection (RET) is involved in the physiological development of some organ systems. Activating RET alterations via either gene fusions or point mutations are potent oncogenic drivers in non-small...
SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34381712/
Resistance is the major cause of treatment failure and disease progression in non-small cell lung cancer (NSCLC). There is evidence that hypoxia is a key microenvironmental stress associated with resistance...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Conclusion/Relevance: “We speculate that SIRT1/PGC-1α/PPAR-γ signaling may represent a molecular metabolic mechanism underlying hypoxia-induced chemoresistance in the NSCLC microenvironment, and targeting hypoxia-related metabolic adaptation may be a potential Show More
Survival of Patients with Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer Treated beyond the Second Line in the Tyrosine Kinase Inhibitor Era
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345514/
Domenico Galetta, Academic Editor Keywords: EGFR-genes, drug therapy, lung cancer, metastasis, survival analysis, TKI In 2020, lung cancer was still the leading cancer worldwide in terms of mortality. NSCLC accounts...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Conclusion/Relevance: “The aim of our retrospective, longitudinal and analytic study was to analyze the survival of EGFR-mutated patients treated beyond the second line of treatment. We confirmed in Show More
EGFR-mutated stage IV non-small cell lung cancer: What is the role of radiotherapy combined with TKI? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34374490/
Lung cancer is the leading cause of cancer-related death globally and poses a considerable threat to public health. Asia has the highest prevalence of epidermal growth factor receptor (EGFR) mutations...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Conclusion/Relevance: “This review focuses on these key issues, and provides a flow diagram with proposed treatment options for metastatic EGFRm NSCLC, aiming to provide guidance for clinical practice.” • The use Show More
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway
Source : https://www.sciencedirect.com/science/article/abs/pii/S094471132100221X?via=ihub
Demethyleneberberine (DMB) is a natural active component of medicinal plant Cortex phellodendri chinensis with favorable bioactivity. However, the role of DMB in suppressing non-small cell lung cancer (NSCLC) remains unknown....