When Blood Disorders Meet Cancer: Uncovering the Oncogenic Landscape of Sickle Cell Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41375813/
Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolysis, vaso-occlusion, and systemic inflammation. Epidemiological studies identified an increased risk of leukemia, especially acute myeloid leukemia (AML), in individuals with...
This review explores increased leukemia risk in sickle cell disease, highlighting links to chronic inflammation, clonal hematopoiesis, impaired immunity, high-risk AML features, and the need for targeted research and prevention strategies.
Sphingosine-1-phosphate receptor modulators resensitize FLT3-ITD acute myeloid leukemia cells with NRAS mutations to FLT3 inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41341164/
FLT3 inhibitor efficacy in AML with FLT3-ITD is short-lived, frequently due to new mutations, most commonly in NRAS . Sphingosine kinase 1 (SPHK1), which phosphorylates sphingosine to generate sphingosine-1-phosphate (S1P),...
S1P receptor modulators (fingolimod, mocravimod) restore FLT3-inhibitor sensitivity in NRAS-mutated FLT3-ITD AML by suppressing SPHK1-RAS signaling, showing in vitro and in vivo efficacy and supporting therapeutic combination potential.
Differences in prognostic value of FLT3 and NPM1 mutations in older and younger patient populations with acute myeloid leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41332821/
The prognostic value of nucleophosmin-1 ( NPM1 ) and fms-like tyrosine kinase 3 ( FLT3 ) mutations has been well-established in adult patients but is less clear in geriatric patients....
Age outweighs FLT3/NPM1 mutations in predicting AML survival; older patients show poor outcomes regardless of mutation profile, while younger patients retain prognostic benefit from favorable molecular subgroups.
Myeloid sarcoma with acute myeloid leukaemia: a case report of rare presentation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41243933/
Myeloid sarcoma (MS) is a rare extramedullary manifestation of acute myeloblastic leukaemia (AML). The presentation of MS depends on the anatomical location being affected. Myeloid sarcoma can also occur in...
Adolescent with abdominal pain and skin lesion was diagnosed with AML and concurrent myeloid sarcoma of cervical nodes; biopsies confirmed diagnosis. Rare presentation underscores need to consider MS in atypical extramedullary symptoms.
Characterization of Chemoresistant Cell Populations Improves Risk Stratification and Therapy Prediction in Pediatric AML - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41256415/
Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet relapse is common, with nearly 40% ultimately dying of the disease. Prognosis is currently assessed using cytogenetic...