An Uncommon Case of Non-leukemic Myeloid Sarcoma of the Face in a 71-year-old Filipino Female: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41536336/
Myeloid sarcoma is a tumor that demonstrates extramedullary proliferation of myeloid blasts with or without maturation. It may present as an isolated tumor or may have peripheral or marrow involvement....
Rare case report describes non-leukemic facial myeloid sarcoma in an elderly woman, highlighting diagnostic challenges, reliance on immunohistochemistry, limited treatment consensus, use of azacitidine, and need for vigilant monitoring for progression to acute myeloid leukemia.
How to Read a Next-Generation Sequencing Report for AML and MDS? What Hematologists Need to Know - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41464583/
Acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are clonal hematopoietic malignancies in which next-generation sequencing (NGS) has become integral for diagnosis, classification, risk stratification, and measurable residual disease (MRD)...
This review guides hematologists in interpreting NGS reports for AML and MDS, explaining technical principles, diagnostic and prognostic implications, MRD assessment, and integration into WHO, ELN, and IPSS-M frameworks.
Extramedullary relapse of acute myeloid leukemia presenting as an epidural spinal mass with vertebral and acetabular leukemic involvement: A case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41492349/
Extramedullary relapse of acute myeloid leukemia (AML) refers to the infiltration of leukemic cells into tissues outside the bone marrow and is a rare occurrence involving central nervous system, particularly...
Azacitidine Beyond the Bone Marrow: An Unexpected Journey Into Azacitidine-Induced Arthropathy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41416281/
Azacitidine, a DNA hypomethylating agent, is a cornerstone in the treatment of myelodysplastic syndromes and acute myeloid leukemia (AML) in patients unfit for intensive chemotherapy. While its adverse effect profile...
Case report highlights rare azacitidine-induced seronegative inflammatory arthropathy in AML, emphasizing immune-mediated toxicity, diagnostic awareness, symptom resolution with corticosteroids, and importance of early recognition to avoid treatment interruption.
When Blood Disorders Meet Cancer: Uncovering the Oncogenic Landscape of Sickle Cell Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41375813/
Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolysis, vaso-occlusion, and systemic inflammation. Epidemiological studies identified an increased risk of leukemia, especially acute myeloid leukemia (AML), in individuals with...
Review explores increased leukemia risk in sickle cell disease, particularly high-risk AML, linking chronic inflammation, clonal hematopoiesis, and impaired immunity, while highlighting knowledge gaps on therapy-related cancer risk and outcomes.