Breakdown of chemo-immune resistance by a TDO2-targeted Pt(IV) prodrug via attenuating endogenous Kyn-AhR-AQP4 metabolic circuity and TLS-promoted genomic instability - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34562469/
A tryptophan-2,3-dioxygenase 2 (TDO2)-targeted Pt(IV) prodrug, DN604-TDOi, was designed to prove that the multi-action compound could overcome drug resistance and relieve immunosuppression via introducing a TDO2 inhibitor to the axial...
The results provided compelling preclinical evidence that TDO2-targeted Pt(IV) prodrug could abrogate immune chemotherapeutic resistance via decaying TDO2-mediated Kyn-AhR-AQP4 immunosuppression and AhR-hpol κ-induced TLS genomic instability, underscoring the development of a novel Pt(IV)-based candidate as a potent immunotherapeutic agent for...
Optimising fusion detection through sequential DNA and RNA molecular profiling of non-small cell lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34536732/
Sequential DNA and RNA based molecular profiling increased the efficacy of detecting fusion driven NSCLCs. Continued optimisation of tissue procurement, handling and the diagnostic pathways for gene fusion analysis is...
Conclusion: Sequential DNA and RNA based molecular profiling increased the efficacy of detecting fusion driven NSCLCs. Continued optimisation of tissue procurement, handling and the diagnostic pathways for gene fusion analysis is necessary to reduce analysis failure rates and improve detection rate for treatment with the next generation of...
How to discriminate non-small cell lung cancer (NSCLC) cases from an Italian administrative database? A retrospective, secondary data use study for evaluating a novel algorithm performance - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34561258/
1 Outcome Research, Healthcare Administration, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) " Dino Amadori", Meldola, Emilia-Romagna, Italy. 2 Outcome Research, Healthcare Administration, IRCCS Istituto Romagnolo per lo...
Conclusion: The algorithm demonstrated a strong validity for identifying NSCLC among patients with lung cancer in hospital administrative databases and can be used to investigate the quality of cancer care for this population.
Prediction Model for Tumor Volume Nadir in EGFR-mutant NSCLC Patients Treated With EGFR Tyrosine Kinase Inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34524205/
doi: 10.1097/RTI.0000000000000615. Online ahead of print. 1 Departments of Imaging Medical Oncology, Dana Farber Cancer Institute Departments of Radiology Medicine, Brigham and Women's Hospital Department of Biostatistics, Harvard Chan School...
The value of innovation: association between improvements in survival of advanced and metastatic non-small cell lung cancer and targeted and immunotherapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34521405/
doi: 10.1186/s12916-021-02070-w. 1 F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland. [email protected]. 2 PHMR Ltd., Westport, Ireland. 3 F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland. 4 Roche...
-
NSCLC Connect4yrKey Points • Conclusion/Relevance: “Our findings expand on the SEER data and provide additional evidence suggesting improvements in survival of patients with advanced and metastatic NSCLC over the past decade could be Show More