Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34671549/
We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical...
Hyperprogressive Disease After Combined Anti-PD-L1 and Anti-CTLA-4 Immunotherapy for MSI-H/dMMR Gastric Cancer: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34631593/
Immune checkpoint inhibitors (ICI) have been developed in gastric adenocarcinomas and approved in first-line metastatic setting (in combination with chemotherapy) as well as in pretreated patients. Microsatellite instability-high (MSI-H) tumors...
Integrins as attractive targets for cancer therapeutics
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463276/
Integrins are transmembrane receptors that have been implicated in the biology of various human physiological and pathological processes. These molecules facilitate cell-extracellular matrix and cell-cell interactions, and they have been...
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NSCLC Connect4yrKey Points • Source: Acta Pharmaceutica Sinica B • Conclusion/Relevance: “Here, we discuss the evidence and knowledge on the contribution of integrins to cancer biology. Furthermore, we summarize the clinical attempts targeting Show More
Combined treatment of non-small cell lung cancer using radiotherapy and immunotherapy: challenges and updates - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34658186/
The efficacy of immunotherapy for advanced non-small cell lung cancer (NSCLC) remains unsatisfactory, as the majority of patients either do not experience an objective response or acquire secondary resistance. As...
Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34597971/
Choroidal metastasis as initial presentation of MTC is extremely rare and challenging to diagnose. Surgeons need a high index of suspicion when ocular symptoms accompany a neck mass or thyroid-related...