ASCO 2020 non-small lung cancer (NSCLC) personal highlights - memo - Magazine of European Medical Oncology
Source : https://link.springer.com/article/10.1007/s12254-020-00673-2
In this article we summarize our personal non-small cell lung cancer (NSCLC) highlights of the virtual ASCO 2020 meeting, covering developments in early and advanced-stage NSCLC. Until recently early stage...
Conclusions:Altogether, ASCO 2020 could excite with inspiring new data for an optimized and more individualized NSCLC treatment regimen, contributing to a better outcome for both early and late-stage diseased patients and continuing to decrease lung cancer mortality.
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JONATHAN SCHWARTZ3yrindividualized? In a society which unethical and immorally rations healthcare with centralized 'evidence based medicine"?
Cost-effectiveness analysis of pegfilgrastim in patients with non-small cell lung cancer receiving ramucirumab plus docetaxel in Japan - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35524869/
doi: 10.1007/s00520-022-07102-6. Online ahead of print. 1 Department of Pharmacy, Toyota Kosei Hospital, 500-1, Ibobara, Jousui-cho, Toyota, 470-0396, Japan. [email protected]. 2 Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4,...
Conclusion: Peg-G is not cost-effective in patients with NSCLC receiving RAM DTX in Japan.
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Jonathan Schwartz3yrNot cost effective??? How ethical a measure is that?? In a free society, the individual gets to determine what is cost effective. In an unethical immoral Show More
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Albert Dekker3yrJapan is cheap and chemo generally at specialized centers
Lobectomy versus segmentectomy in patients with stage T (> 2 cm and ≤ 3 cm) N0M0 non-small cell lung cancer: a propensity score matching study - Journal of Cardiothoracic Surgery
Source : https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-022-01867-x
Background The safety and effectiveness of lung segmentectomy in patients with early non-small cell lung cancer (NSCLC) remains controversial. We have therefore reviewed the clinicopathologic characteristics and survival outcomes of...
Conclusions: Patients with stage T (> 2 and ≤ 3 cm) N0M0 NSCLC undergoing segmentectomy can obtain OS and LCSS similar to those obtained with lobectomy. Further studies are required considering the solid component effects and pathologic tumor types regarding segmentectomies. Additional long-term survival and outcome analyses should be...
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NSCLC Connect3yrThis study uses a network meta-analysis (NMA). The use of NMAs can be debatable because they compare agents indirectly across reviews. What are your thoughts on NMAs?
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NSCLC Connect3yrKey Points • Source: Journal of Cardiothoracic Surgery • Conclusions: “Patients with stage T (> 2 and ≤ 3 cm) N0M0 NSCLC undergoing segmentectomy can obtain OS and LCSS [lung cancer-specific survival] similar to those obtained with Show More
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New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2
Source : https://www.wjgnet.com/2218-4333/full/v13/i4/276.htm
Approximately 60% of lung adenocarcinomas harbour molecular alterations in driver oncogenes, with incidence, which varies according to ethnic origin and alteration, as follows: epidermal growth factor receptor (EGFR) mutation, 15%-20%[...
Conclusion/Relevance: Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets, including RET, NTRK fusions, c-MET alterations, and activating mutations in KRAS, BRAF, and HER2, all with frequencies greater than 1%. Lung cancers harbouring these genome changes can potentially be treated with agents...
De- "bug"-ing the microbiome in lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35588337/
The identification of microbes enriched in the healthy lung has led to the compelling discovery that microbes may contribute to lung cancer pathogenesis. Here, we review the recent literature showing...
Relevance: The identification of microbes enriched in the healthy lung has led to the compelling discovery that microbes may contribute to lung cancer pathogenesis. Here, we review the recent literature showing microbial associations with lung cancer as well as the functional features that have been identified in human and murine studies.