Prognostic Impact of Using Combined Plasma Fibrinogen Level and Neutrophil-to-Lymphocyte Ratio in Resectable Non-small Cell Lung Cancer - Annals of Surgical Oncology
Source : https://link.springer.com/article/10.1245/s10434-022-11835-3
Background Both plasma fibrinogen level and neutrophil-to-lymphocyte ratio (NLR) are associated with malignant potential in different cancer types. The current study evaluated the use of combined plasma fibrinogen level and...
Conclusions: The F-NLR score, which is based on histological inflammation and coagulability, could be a potential prognostic indicator in patients with resectable NSCLC.
All EGFR mutations are (not) created equal: focus on uncommon EGFR mutations - Journal of Cancer Research and Clinical Oncology
Source : https://link.springer.com/article/10.1007/s00432-022-04033-x
Purpose Most common EGFR mutations in NSCLC include del19 and exon 21 L858R. Approximately 10% of patients have uncommon EGFR mutations (indels, missense mutations involving G719, L861 and S768 codons,...
Conclusion: The current study highlighted that rare/dual EGFR mutations are heterogeneous with distinct clinical features in a large Indian cohort of EGFR mutated patients with NSCLC.
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Albert Dekker3yrthey are still rare
Identifification of a novel LDLR-RET Fusion in Lung Adenocarcinoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35524867/
doi: 10.1007/s10637-022-01246-2. Online ahead of print. 1 Nantong Hospital of Shanghai University, 226013, Nanting, Nantong, Jiangsu, China. 2 Hangzhou D.A. Medical Laboratory, 310030, Hangzhou, China. 3 The Prople's Hosptial of...
Conclusions: This novel form of RET fusion in NSCLC is reported for the first time worldwide, offering a new treatment option for the patient with the possibility of using RET-selective inhibitors.
Surgical Evaluation in Patients Undergoing Radiation Therapy for Early-stage Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35609647/
Among patients with early-stage NSCLC undergoing SBRT as primary treatment, a minority are evaluated by a thoracic surgeon. Because they have a longer time-to-treatment, more invasive diagnostic procedures, and higher...
Conclusions: Among patients with early-stage NSCLC undergoing SBRT as primary treatment, a minority are evaluated by a thoracic surgeon. Because they have a longer time-to-treatment, more invasive diagnostic procedures, and higher costs, this represents a targetable gap to make workup protocols more efficient.
Molecular profiling of non-small-cell lung cancer patients with or without brain metastases included in the randomized SAFIR02-LUNG trial and association with intracranial outcome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35609409/
doi: 10.1016/j.lungcan.2022.05.004. Online ahead of print. 1 Aix Marseille Univ, APHM, INSERM, CNRS, CRCM, Hôpital Nord, Multidisciplinary Oncology and Therapeutic Innovations Department, Marseille, France. 2 Université Paris-Saclay and Medical Oncology,...
Conclusion: This work identified a 24-gene signature specific to lung cancer with BM. Further studies are needed to precisely determine the functional implications of these genes to identify new therapeutic targets for the treatment of lung cancer with BM.