Overcoming resistance to antibody-drug conjugates: mechanisms and emerging strategies. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41630503
Explore mechanisms of resistance to antibody-drug conjugates in cancer therapy, including breast, lung, pancreatic, and leukemia, and emerging strategies to overcome these barriers for improved treatment outcomes.
This review identifies resistance pathways in ADC therapy for cancers like breast, lung, pancreatic, and leukemia, suggesting strategies to enhance efficacy through combination treatments.
Challenging and Successful Therapy Decision-Making for AML Post Cytotoxic Therapy and Concomitant Active Breast Cancer - A Case Report and Experience-Driven Strategy. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41877816
Discover a case report of AML-pCT remission post-alloHCT in a patient with active breast cancer, emphasizing interdisciplinary collaboration.
Successful intensive alloHCT resulted in complete remission of AML-pCT. Collaboration between oncologists and hematologists was crucial. Disease Condition: AML-pCT and active BC.
Glycolysis and glycolytic enzymes in acute myeloid leukemia: Warburg and beyond - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42244861/
The ability to generate and regulate energy, maintain metabolic flux, and preserve redox homeostasis is the basis of all cellular processes in both healthy and diseased tissues. While the importance...
Review highlights that acute myeloid leukemia cells rely on enhanced glycolysis and overexpress glycolytic enzymes, which have both metabolic and non-metabolic roles in signaling, redox regulation, and therapy resistance, making them promising therapeutic targets.
Efficacy and safety of FLT3 inhibitors for acute myeloid leukemia: a network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42200022/
identifier CRD420251267673.
Network meta-analysis found FLT3 inhibitors improve remission and survival in AML, with gilteritinib showing the strongest efficacy, while maintaining an acceptable safety profile despite increased adverse events.
Leukemia Cutis in Acute Myeloid Leukemia: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42147687/
Leukemia cutis is an uncommon extramedullary manifestation of acute myeloid leukemia (AML) caused by infiltration of the skin by leukemic blasts. Its clinical morphology is highly variable and may mimic...
Case highlights leukemia cutis as an extramedullary manifestation of AML, presenting with multifocal nodular and ulcerative skin lesions and gingival hyperplasia, where skin biopsy confirmed cutaneous myeloid sarcoma with adverse prognostic implications.