Utility of Cerebrospinal Fluid Cell-Free DNA in Patients with EGFR-Mutant Non-Small-Cell Lung Cancer with Leptomeningeal Metastasis
Source : https://link.springer.com/article/10.1007/s11523-021-00791-9
Background Leptomeningeal metastasis (LM) is a fatal complication of advanced non-small-cell lung cancer (NSCLC). Objective The aim of this study was to evaluate the utility of cerebrospinal fluid (CSF) as...
Synergy between early-incorporation immunotherapy and extracranial radiotherapy in metastatic non-small cell lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33569310/
Utilization of RT + eIT in mNSCLC is increasing. SBRT + eIT was associated with improved OS on propensity-score matched analysis. There were no significant differences in OS based on...
Evaluation of Serum Biomarker CEA and Ca-125 as Immunotherapy Response Predictors in Metastatic Non-small Cell Lung Cancer
Source : https://ar.iiarjournals.org/content/41/2/869.abstract
Background/Aim: Treatment options for advanced non-small cell lung cancer (NSCLC) include immunotherapy. Elevated carcinoembryonic antigen (CEA) and cancer antigen 125 (Ca-125) levels are associated with poorer prognoses of resected NSCLC,...
Differential expression profiling of transcripts of IDH1, CEA, Cyfra21-1, and TPA in stage IIIa non-small cell lung cancer (NSCLC) of smokers and non-smokers cases with air quality index
Source : https://www.sciencedirect.com/science/article/pii/S0378111920308209?via=ihub
For the Lung cancer risk, this study compared the smoking habit with residential exposure of air pollution (Air Quality Index of the city). * Increased levels of IDH1 and CEA...
Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
Source : https://www.nature.com/articles/s41416-020-01135-6
Cyclin-dependent kinase 9 (CDK9) is a promising prognostic marker and therapeutic target in cancers. Bufalin is an effective anti-tumour agent; however, the clinical application of bufalin is limited due to...