NSCLC Connect
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5yr

EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non-Small Cell Lung Cancer - PubMed

EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non-Small Cell Lung Cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34127383/

Although phenotypically similar to patients with common EGFR mutations, patients with EGFR ex20-mut had worse survival, perhaps due to the lack of targeted therapies. Chemotherapy was superior to conventional EGFR...

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    Key Points • In the current retrospective study, 109 Australian patients with NSCLC harboring epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20-ins) (excluding T790M) were assessed for clinical characteristics Show More
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5yr

Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis - PubMed

Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34126551/

Osimertinib appears to be the most effective and safest treatment in NSCLC patients with brain metastases, harboring EGFR positive mutations. The anti-PD1 monoclonal antibody and conventional chemotherapy combination increases survival...

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5yr

Prediction of lymph nodes micrometastasis in NSCLC - CMAR | CMAR

Prediction of lymph nodes micrometastasis in NSCLC - CMAR | CMAR

Source : https://www.dovepress.com/machine-learning-for-the-prediction-of-lymph-nodes-micrometastasis-in--peer-reviewed-fulltext-article-CMAR

Globally, lung cancer cases and deaths remain rising over the past decade. In 2018, the Global Cancer Observatory Organization (GLOBOCAN) estimated more than 2 million new cases and 1.76 million...

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5yr

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Source : https://www.nature.com/articles/s41586-021-03651-8

Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target for cancer treatment1,2. However, modulating macrophages has...

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5yr

Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients - PubMed

Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34107412/

Liquid biopsies have become of interest as minimally invasive ways to monitor treatment response in lung cancer patients. Circulating tumor DNA (ctDNA) and protein biomarkers are evaluated for their added...