Digital PCR detection of EGFR somatic mutations in non-small-cell lung cancer formalin fixed paraffin embedded samples - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34089806/
doi: 10.1016/j.mcp.2021.101745. Online ahead of print. 1 Laboratório de Genética Molecular Humana, Universidade Federal Do Paraná, Curitiba, Brazil. 2 Laboratório de Genética Molecular Humana, Universidade Federal Do Paraná, Curitiba, Brazil;...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Digital PCR (dPCR) could replace real time PCR and Sanger sequencing in the detection/quantification of rare mutations, such as EGFR. In the current study, researchers compared the performance Show More
EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non-Small Cell Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34127383/
Although phenotypically similar to patients with common EGFR mutations, patients with EGFR ex20-mut had worse survival, perhaps due to the lack of targeted therapies. Chemotherapy was superior to conventional EGFR...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • In the current retrospective study, 109 Australian patients with NSCLC harboring epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20-ins) (excluding T790M) were assessed for clinical characteristics Show More
Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34126551/
Osimertinib appears to be the most effective and safest treatment in NSCLC patients with brain metastases, harboring EGFR positive mutations. The anti-PD1 monoclonal antibody and conventional chemotherapy combination increases survival...
Prediction of lymph nodes micrometastasis in NSCLC - CMAR | CMAR
Globally, lung cancer cases and deaths remain rising over the past decade. In 2018, the Global Cancer Observatory Organization (GLOBOCAN) estimated more than 2 million new cases and 1.76 million...
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
Source : https://www.nature.com/articles/s41586-021-03651-8
Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target for cancer treatment1,2. However, modulating macrophages has...