Immune checkpoint inhibitors combined with chemotherapy/bevacizumab therapy for patients with advanced lung cancer and heavily treated with EGFR mutation: a retrospective analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34164187/
Background: EGFR-mutated lung cancer poorly responded to anti-programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy. Whether patients with EGFR-mutated lung cancer can benefit from anti-PD-1/PD-L1 therapy combined with other drugs remains...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • In the current study, researchers retrospectively assessed whether 56 patients with EGFR-mutated lung cancer were effectively be treated with PD-1/PD-L1 therapy plus chemotherapy with or without bevacizumab. These Show More
A new sensitive and fast assay for the detection of EGFR mutations in liquid biopsies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34166445/
For profiling clinical plasma samples, characterized by low ctDNA abundance, the SensiScreen® EGFR Liquid assay is able to identify down to 1 copy of mutant alleles and with its high...
p65BTK Is a Novel Biomarker and Therapeutic Target in Solid Tumors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34164404/
Bruton's tyrosine kinase (BTK) is a non-receptor intracellular kinase playing a key role in the proliferation and survival of normal and malignant B-lymphocytes. Its targeting by Ibrutinib, the first specific...
Acquired Tertiary MET Resistance (MET D1228N and a Novel LSM8-MET Fusion) to Selpercatinib and Capmatinib in a Patient With KIF5B-RET-positive NSCLC With Secondary MET Amplification as Initial Resistance to Selpercatinib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34154791/
Acquired Tertiary MET Resistance (MET D1228N and a Novel LSM8-MET Fusion) to Selpercatinib and Capmatinib in a Patient With KIF5B-RET-positive NSCLC With Secondary MET Amplification as Initial Resistance to Selpercatinib
Digital PCR detection of EGFR somatic mutations in non-small-cell lung cancer formalin fixed paraffin embedded samples - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34089806/
doi: 10.1016/j.mcp.2021.101745. Online ahead of print. 1 Laboratório de Genética Molecular Humana, Universidade Federal Do Paraná, Curitiba, Brazil. 2 Laboratório de Genética Molecular Humana, Universidade Federal Do Paraná, Curitiba, Brazil;...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Digital PCR (dPCR) could replace real time PCR and Sanger sequencing in the detection/quantification of rare mutations, such as EGFR. In the current study, researchers compared the performance Show More