Impact of docetaxel plus ramucirumab in a second-line setting after chemoimmunotherapy in patients with non-small-cell lung cancer: A retrospective study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34791812/
doi: 10.1111/1759-7714.14236. Online ahead of print. 1 Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 2 Department of Respiratory Medicine, Japanese Red...
Conclusion/Relevance: Our retrospective observations suggest that the group with longer PFS with chemoimmunotherapy might be expected to benefit from docetaxel plus ramucirumab treatment in second-line settings for patients with advanced NSCLC.
Dual role of IL-37 in the progression of tumors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34800851/
Interleukin (IL)-37 is a novel defined cytokine that belongs to IL-1 family, which possesses potent anti-inflammatory and immunosuppressive properties. The IL-37 protein mainly exists in the cytoplasm of monocytes and...
Relevance: In this review, we will summarize the role of IL-37 in the microenvironment of different tumors, hoping to provide novel perspectives towards the mechanism, prevention, and treatment of tumors.
Unique genomic alterations of cerebrospinal fluid cell-free DNA are critical for targeted therapy of non-small cell lung cancer with leptomeningeal metastasis
Source : https://www.sciencedirect.com/science/article/pii/S0888754321003980?via=ihub
We reported unique molecular features of cerebrospinal fluid (CSF) of NSCLC patients with leptomeningeal metastasis (LM), suggesting to establish CSF as a better liquid biopsy in clinical practices. We performed...
Conclusion:We reported unique molecular features of cerebrospinal fluid (CSF) of NSCLC patients with leptomeningeal metastasis (LM), suggesting to establish CSF as a better liquid biopsy in clinical practices.
The Effect of Body Mass Index on Treatment Outcomes in Patients with Metastatic Non-Small Cell Lung Cancer Treated with Platinum-Based Therapy 1.
Source : https://oncologynation.com/journal/61967
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A high BMI prior to therapy in patients with NSCLC treated with platinum-based ChT in the first-line setting was associated with more favorable PFS and OS.
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NSCLC Connect4yrKey Points • Source: Nutrition and Cancer • Conclusion/Relevance: “A high BMI prior to therapy in patients with NSCLC treated with platinum-based ChT [chemotherapy] in the first-line setting was associated with more favorable PFS Show More
The pan-tumor landscape of targetable kinase fusions in circulating tumor DNA - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753780/
Targetable kinase fusions are identified in ctDNA across cancer types. In pairs with tissue-identified fusions, fusion detection in ctDNA is reliable with elevated ctDNA fraction. These data support the validity...
Targetable kinase fusions are identified in ctDNA across cancer types. In pairs with tissue-identified fusions, fusion detection in ctDNA is reliable with elevated ctDNA fraction. These data support the validity of CGP to enable ctDNA-based fusion detection for informing clinical care in advanced cancer.