Conclusion: The results of this study suggest that biologic agents have the same utility for patients who identify as Black as they do for those who identify as White.
Optimized Dosing: The Next Step in Precision Medicine in Non-Small-Cell Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34894338/
In oncology, and especially in the treatment of non-small-cell lung cancer (NSCLC), dose optimization is often a neglected part of precision medicine. Many drugs are still being administered in "one...
Conclusion/Relevance: This review of the literature provides recommendations on the implementation of dose optimization and advice regarding promising strategies that deserve further research in NSCLC.
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NSCLC Connect4yrKey Points • Source: Drugs • Conclusion/Relevance: “This article focuses on the evidence for the most promising and easily implemented optimized dosing approaches for the small-molecule inhibitors, chemotherapeutic agents, and monoclonal antibodies as treatment Show More
Pralsetinib (Gavreto): Treatment of metastatic non-small-cell lung cancer in patients positive for RET fusions
AbstractDisclaimer. In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manu
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Conclusion: Pralsetinib is a unique targeted tyrosine kinase inhibitor approved for the treatment of patients with RET fusion–positive NSCLC who may desire a once-daily regimen. The recent approval of pralsetinib represents an important addition for the treatment of patients with RET fusion–positive NSCLC.
A mimic of lung adenocarcinoma: a case report of histological conversion of metastatic thyroid papillary carcinoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34843113/
In a patient with a history of cancer, distinguishing a metastasis of the prior tumour from a new primary tumour relies on the comparison of morphological features between the tumour...
Conclusion: Through the analysis of thyroid tumor and lung tumor at the age of 4 and 34 years in this patient, identical NCOA4-RET translation suggested histological conversion, which was induced probably due to high selective pressure by the treatment. As histological transformation of non-small cell lung cancer is well documented as a form of...
Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non‐small cell lung cancer
Source : https://onlinelibrary.wiley.com/doi/10.1002/cam4.4472
Suzhen Wang , Qinghua Wang , Corresponding Author Department of Health Statistics, Key Laboratory of Medicine and Health of Shandong Province, School of Public Health, Weifang Medical University, Weifang, China...
Conclusion: Our investigation indicates that PTPRT mutations may be considered as a potential indicator for assessing ICI efficacy in melanoma and NSCLC, even across multiple cancers. Further prospective validation cohorts are warranted.