Less Is More, But Me-Too Should Not Be the Strategy for Lung Cancer Treatment in 2026 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41950438/
Although immune checkpoint inhibitors (ICIs) and targeted therapies (TTs) have transformed the treatment of non-small cell lung cancer (NSCLC) across disease stages, real-world access remains highly unequal worldwide. Persistent cost...
Review argues lung cancer treatment should prioritize dose optimization over proliferation of “me-too” drugs, addressing cost, access disparities, and regulatory inconsistencies while maintaining efficacy and improving sustainability and patient outcomes.
A Subgroup Analysis of Perioperative Pembrolizumab in Clinical Stage II Non-Small-Cell Lung Cancer from the Randomized KEYNOTE-671 Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41875364/
ClinicalTrials.gov, NCT03425643, registered/first posted on February 7, 2018 (https://www.clinicaltrials.gov/study/NCT03425643).
Perioperative pembrolizumab plus chemotherapy improves event-free survival, pathological response, and resection outcomes in stage II NSCLC, with manageable safety, supporting its use over chemotherapy alone.
Phase Ia trial protocol tests intrathecal pemetrexed + bevacizumab safety (primary) and OS (secondary) in NSCLC-LM patients, using Cohort A (pemetrexed monotherapy) for safety run-in and Cohort B (combo) with 3+3/ATD bevacizumab dose escalation.
An Early-Stage Nuclear Protein in Testis Carcinoma of the Lung in an Older Woman - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41339294/
A nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy often diagnosed late due to non-specific symptoms and low awareness. A 69-year-old woman presented with haemoptysis and a...
Rare early-stage pulmonary NUT carcinoma in an older woman was initially misdiagnosed on biopsy; definitive diagnosis required immunohistochemistry and FISH, highlighting need for high suspicion and comprehensive evaluation.
Misdiagnosis of superior sulcus tumours: a scoping review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41816482/
Explicit testing and differentiation between shoulder and cervical spine pathology are required when examining patients with atraumatic shoulder and/or arm pain to rule out SSTs. Specifically, targeted testing for cervical...
Scoping review of superior sulcus tumors found frequent misdiagnosis as musculoskeletal disorders, especially cervical radiculopathy or shoulder osteoarthritis, causing diagnostic delays; careful differentiation and targeted imaging are essential for early detection.