Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer
Source : https://www.sciencedirect.com/science/article/pii/S2468294222000466?via=ihub
High systemic inflammation is common in advanced stage lung cancer and is an independent strong predictor of poor outcomes. * A high inflammation score has an independent survival impact equal...
Conclusion: Our results show that high level systemic inflammation is a strong independent predictor of poor survival in advanced stage NSCLC. This observation may indicate a need to use hyperinflammation as an additional clinical parameter for stratification of patients in clinical studies and warrants further research on underlying...
Effect of kangai injection combined with platinum-based chemotherapy on the immune function of patients with advanced non-small-cell lung cancer: A meta-analysis
Source : https://www.sciencedirect.com/science/article/abs/pii/S0944711322001660?via=ihub
Kangai injection (KAI) is a well-known Chinese patent medicine applied for several different types of cancers in the clinic as an auxiliary therapeutic approach, which is refined from three herbal...
Conclusions: This meta-analysis identified that the combination treatment of KAI and platinum-based chemotherapy was more beneficial to patients with advanced NSCLC when compared to chemotherapy alone, which could significantly improve the clinical efficacy, enhance the immune function, and reduce chemotherapy toxicity. Our study provides a...
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Albert Dekker4yrwhat is kangai?
CirRNA circFAM126A Exerts Oncogenic Functions in NSCLC to Upregulate IRS2 - Biochemical Genetics
Source : https://link.springer.com/article/10.1007/s10528-022-10212-9
Non-small cell lung cancer (NSCLC) is a common histological subtype of lung cancer, which occupies 80-85% of the proportion in all lung cancer cases. Therefore, this study was designed to...
Conclusions/Relevance: Consistently, the silencing of circFAM126A also functioned anti-tumorigenic roles in nude mice in vivo. Mechanistically, circFAM126A could function as a miRNA sponge for miR-613 to regulate the expression of IRS2, thereby regulating proliferation, migration, invasion, apoptosis, and cell cycle arrest in NSCLC cells.
Neoadjuvant chemoradiotherapy is superior to chemotherapy alone in surgically treated stage III/N2 non-small-cell lung cancer: a retrospective single-center cohort study
Source : https://www.esmoopen.com/article/S2059-7029(22)00084-9/fulltext
Despite all novel treatment options, stage III non-small-cell lung cancer (NSCLC) patients still have a poor prognosis with a median overall survival (OS) of 42, 22 and 11 months in...
Conclusions: In this retrospective PS-matched long-term analysis, neoadjuvant CHT/RT conferred improved DFS and OS compared with CHT alone in stage III/N2 NSCLC. These highly challenging results require confirmation in well-designed randomized controlled trials conducted at highly specialized thoracic oncology centers.
RELAY+: Exploratory Study of Ramucirumab Plus Gefitinib in Untreated Patients With EGFR-Mutated Metastatic NSCLC
Source : https://www.jtocrr.org/article/S2666-3643(22)00027-3/fulltext
Ramucirumab (RAM) plus erlotinib was found to have superior progression-free survival (PFS) versus placebo plus erlotinib in untreated EGFR-mutated metastatic NSCLC in the global phase 3 RELAY study. RELAY+ was...
Conclusions: RELAY was found to have a favorable benefit–risk profile for RAM plus GEF in first-line treatment of East Asian patients with EGFR-mutated NSCLC.