Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139342/
Cells. 2022 May; 11(10): 1694. Chike Osude, 1 Leo Lin, 1 Meet Patel, 1 Adam Eckburg, 1 Joseph Berei, 1 Adijan Kuckovic, 1 Namrata Dube, 1 Aayush Rastogi, 1 Shruti...
Conclusion: These results indicate that VEGFR-2 may play a key role in EGFR-TKI resistance that can be overcome with a combination treatment of Erlotinib and a VEGFR-2 inhibitor, which may serve as an effective treatment option for NSCLC patients with EGFR mutations.
Meaning: These findings suggest that in NSCLC, a high number of nonsynonymous tumor mutations is associated with immune cell infiltration and inflammatory T-cell expression signatures, leading to increased sensitivity to PD-1/PD-L1 inhibition across PD-L1 expression subgroups.
Cost-effectiveness analysis of pegfilgrastim in patients with non-small cell lung cancer receiving ramucirumab plus docetaxel in Japan - Supportive Care in Cancer
Source : https://link.springer.com/article/10.1007/s00520-022-07102-6
Purpose The dose-limiting factor of ramucirumab plus docetaxel (RAM + DTX) in patients with non-small cell lung cancer (NSCLC) is febrile neutropenia (FN), which has a high incidence in Asians. This study...
Conclusion: Peg-G is not cost-effective in patients with NSCLC receiving RAM DTX in Japan.
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Albert Dekker3yralmost anything is cost effective in Japan
Characterization of a Novel LUCAT1/miR-4316/VEGF-A Axis in Metastasis and Glycolysis of Lung Adenocarcinoma
Source : https://www.frontiersin.org/articles/10.3389/fcell.2022.833579/full
Objective: Accumulating literatures suggested that long non-coding RNAs (lncRNAs) were involved in tumorigenesis and cancer progression in lung adenocarcinoma (LUAD). However, the precise regulatory mechanism of lncRNA Lung cancer-associated transcript...
Conclusion: Our present research suggested that LUCAT1 facilitate LUAD cell metastasis and glycolysis via serving as a competing endogenous RNA to regulate miR-4316/VEGFA axis, which provided a novel diagnostic marker and therapeutic target for LUAD patients.
Development and validation of a case-finding algorithm for the identification of non-small cell lung cancers in a region-wide Italian pathology registry
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269232
Purpose To develop and validate a case-finding algorithm for the identification of Non-Small Cell Lung Cancer (NSCLC) cases in a region-wide Italian pathology registry (PR). Materials and methods Data collected...
Conclusions: The final NSCLC-finding algorithm showed with very high PPV. SE was in line with the expected contribution of PR to overall cases captured in the regional Cancer Registry, with a trend of increase over calendar time. Given the promising algorithm validity and the wide use of SNOMED terminology in electronic pathology records, the...