RELAX trial shows venetoclax plus cytarabine and mitoxantrone yields high remission rates (75%) in relapsed/refractory AML with manageable safety, supporting its use as an effective salvage and bridge-to-transplant strategy.
Clinical Integration of Menin Inhibitors in AML: Evolving Data and Therapeutic Perspectives - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41799513/
Acute myeloid leukemia (AML) remains a biologically heterogeneous disease with historically limited targeted therapies and poor outcomes. The development of menin inhibitors represents a promising shift, particularly for patients harboring...
Review details menin inhibitors (revumenib, ziftomenib, bleximenib, icovamenib) for KMT2Ar/NPM1m AML, showing high CRc rates (53-100%), MRD negativity, and manageable AEs (DS 27%, QTc prolongation 29%) in R/R and frontline settings.
Acute myeloid leukemia presenting with gingival enlargement masked by a normal complete blood count: A case of delayed diagnosis and literature review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41430963/
This case underscores the notion that gingival enlargement can serve as an initial indicator of AML, even in the absence of conventional hematological abnormalities. Dentists are required to exercise a...
Acute myeloid leukemia may present as gingival enlargement despite normal initial blood counts, leading to delayed diagnosis; persistent symptoms warrant repeated evaluation and suspicion of systemic disease to enable timely treatment.
Overcoming resistance to immune checkpoint inhibitor therapy in acute myeloid leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41815556/
Acute myeloid leukemia (AML) is characterized by molecular, immunological, and clinical heterogeneity and this has been reflected with changing paradigms in the treatment landscape of AML in recent years. Despite...
Review examines limited effectiveness of immune checkpoint inhibitors in AML due to immune-cold microenvironment and T-cell dysfunction, outlining resistance mechanisms and highlighting omics-guided stratification and combination immunotherapies to improve responses.
Acute promyelocytic leukemia with a novel TTMV::RARA fusion initially presenting as vertebral myeloid sarcoma: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41777660/
This report presents a rare adult case of TTMV::RARA acute promyelocytic leukemia presenting as vertebral myeloid sarcoma. Whole-transcriptome sequencing was essential for diagnosis after routine molecular tests were negative, highlighting...
Case report describes rare acute promyelocytic leukemia with novel TTMV::RARA fusion initially presenting as vertebral myeloid sarcoma; diagnosis required whole-transcriptome sequencing after negative routine tests, highlighting importance of detecting rare RARA variants.